LINGain

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Prospective evaluation of predictive/prognostic immunogenicity biomarkers for target therapy in HER2-positive early breast cancer within the PHERGain clinical study.

The LINGain project, as a substudy of the PHERGain trial, has the potential interest to identify immunogenicity biomarkers of response or resistance linked to targeted anti-HER2 therapy. In this exploratory and comprehensive study, we hypothesize that the activation of the different subtypes of γδ T cells in peripheral blood during dual HER2 blockade with trastuzumab and pertuzumab is a signal of immune response, and it could be considered an early marker useful to predict the efficacy of biological therapy in patients with HER2-positive early breast cancer.

NAME TUMOR TYPE TITLE PHASE N SITES COUNTRY STATUS
LINGain
HER2+ EBC Prospective evaluation of predictive/prognostic immunogenicity biomarkers for target therapy in HER2-positive early breast cancer within the PHERGain clinical study Sub-study 42 5 Spain Actively enrolling patients

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