PALMIRA
OFFICIAL TITLE: PALBOCICLIB RECHALLENGE IN HORMONE RECEPTOR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER – PALMIRA.
CLINICAL TRIAL DETAILS
INTERNATIONAL, MULTICENTER, RANDOMIZED, OPEN-LABEL, PHASE II CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF CONTINUATION OF PALBOCICLIB IN COMBINATION WITH SECOND-LINE ENDOCRINE THERAPY IN HORMONE RECEPTOR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER PATIENTS WHO HAVE ACHIEVED CLINICAL BENEFIT DURING FIRST-LINE PALBOCICLIB-BASED TREATMENT.
THE PRIMARY GOAL IS TO COMPARE THE EFFICACY, DEFINED AS PROGRESSION-FREE SURVIVAL (PFS), OF CONTINUATION OF PALBOCICLIB TREATMENT COMBINED WITH SECOND-LINE ENDOCRINE THERAPY (FULVESTRANT OR LETROZOLE) VERSUS ENDOCRINE THERAPY ALONE IN PRE- AND POST-MENOPAUSAL WOMEN WITH HR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER (ABC).
IN ADDITION, TO EXPLORE POTENTIAL MOLECULAR MARKERS OF SENSITIVITY AND/OR RESISTANCE FOR THE COMBINATION AND ENDOCRINE THERAPY ALONE.
PALMIRA AT CLINICALTRIALS.GOV
TUMOR TYPE
PHASE
N
SITES
COUNTRY
STATUS
HER2+ ABC
II
198
54
Spain, France, Italy, UK, Germany, Slovenia
Closing
PRESS RELEASE
SCIENTIFIC IMPACT
ASCO 2023 – DOWNLOAD THE PRESENTATION
ASCO 2023 - DOWNLOAD THE LAY LANGUAGE SUMMARY
PALMIRA CASE STUDY 2023 - DOWNLOAD
ESMO 2019 – DOWNLOAD THE POSTER
BLOG ARTICLES RELATED
SPAIN
Hospital Arnau de Vilanova
SPAIN
Instituto Valenciano de Oncología (IVO)
SPAIN
Hospital Universitari i Politècnic La Fe
SPAIN
Consorci Hospital General Universitari de València
SPAIN
Hospital Provincial de Castellón
SPAIN
Hospital Universitari Vall D'Hebron
SPAIN
Hospital del Mar
SPAIN
Instituto Oncológico Baselga - Hospital Quiron Salud Barcelona
SPAIN
Institut Català d' Oncologia L'Hospitalet (ICO)
SPAIN
Institut Català d' Oncologia Badalona (ICO)
SPAIN
Institut Català d' Oncologia Girona (ICO)
SPAIN
Consorci Hospitalari de Terrassa
SPAIN
Hospital Universitari Sant Joan de Reus
SPAIN
Hospital Universitario Arnau de Vilanova de Lleida
SPAIN
Hospital Universitari Son Espases
SPAIN
Hospital Clínico Universitario Lozano Blesa
SPAIN
Hospital Universitario Miguel Servet
SPAIN
Hospital Clínico San Carlos
SPAIN
Hospital Universitario La Paz
SPAIN
Hospital Universtitario Sanchinarro
SPAIN
Hospital Universitario de Basurto
SPAIN
Centro Oncológico de Galicia
SPAIN
Hospital Álvaro Cunqueiro
SPAIN
Hospital Universitario Virgen del Rocío
SPAIN
Hospital Universitario Virgen de la Macarena
SPAIN
Hospital Regional Universitario de Málaga (Hospital Carlos Haya)
SPAIN
Hospital San Pedro de Alcántara
FRANCE
Hopital Europeen Georges Pompidou
FRANCE
Hôpital Tenon AP-HP
FRANCE
Centre Paul Strauss
FRANCE
Hôpital Jean Minjoz
FRANCE
Centre Georges François Leclerc
FRANCE
Hospital Center Departmental Vendée
ITALY
Instituto Europeo di Oncologia
ITALY
Ospedale San Raffaello
ITALY
Ospedale Civili Brescia
ITALY
Policlinico Universitario Campus Bio-medico, Roma
UK
Barts Cancer Institute
UK
Beatson West of Scotland Cancer Center
UK
Maidstone- Kent Oncology Department
UK
Abertawe Bro Morgannwg University Local Health Board, Singleton Hospital
UK
Royal Cornwall Hospital NHS Trust
UK
Darent Valley Hospital by Dartford and Gravesham NHS Trust
GERMANY
Technical University Munich
GERMANY
Klinikum Mutterhaus der Borromäerinnen Trier
GERMANY
Kliniken Essen Mitte
GERMANY
UKM Brustzentrum
GERMANY
University Hospital Dresden-GYN
GERMANY
Klinikum Ernst von Bergmann
GERMANY
Universitätsklinikum Essen Frauenklinik
GERMANY
AGAPLESION Markus Krankenhaus
SLOVENIA
Onkološki Inštitut Ljubljana
SLOVENIA
Univerzitetni klinicni center Maribor Oddelek za onkologijo